Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy


Gurbanova A. A. , GÜLHAN R., Berkman K., Onat F. , van Rijn C. M. , van Luijtelaar G.

BRITISH JOURNAL OF PHARMACOLOGY, vol.148, no.8, pp.1076-1082, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 148 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1038/sj.bjp.0706791
  • Title of Journal : BRITISH JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.1076-1082
  • Keywords: cortical focus theory, absence epilepsy, GAERS, WAG/Rij, phenytoin, spike-wave discharges, ethosuximide, genetic models, translation research, SPIKE-WAVE DISCHARGES, CELLULAR MECHANISMS, SODIUM-CHANNELS, RAT MODEL, SEIZURES, CORTEX, BRAIN, THALAMUS, NEURONS, DYSREGULATION

Abstract

1 Spontaneous 7-10 Hz spike-wave discharges (SWDs) are the electroencephalographic hallmark of absence seizures, as can be observed in WAG/Rij as well as in GAERS, two commonly used well-validated genetic rat models of absence epilepsy. A local upregulation of sodium channels within the perioral region of the primary somatosensory cortex indicated an initiation site for SWDs in WAG/Rij rats, in line with a new theory that assumes that SWDs have a cortical focal origin in the perioral region of the somatosensory cortex. We tested whether bilateral microinfusion at this focal site of the sodium channel blocker phenytoin, which is known to aggravate SWDs after systemic administration, reduces SWDs in both models.