Pregnancy-associated plasma protein-A and asthma

COSKUN A., Balbay O., Duran S., Annakkaya A. N., Bulut I., Yavuz O., ...More

ADVANCES IN THERAPY, vol.24, no.2, pp.362-367, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1007/bf02849905
  • Journal Name: ADVANCES IN THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.362-367
  • Keywords: asthma, atherosclerosis, IGF, IGFBP-4, PAPP-A, AIRWAY SMOOTH-MUSCLE, GROWTH-FACTORS, BRONCHIAL-ASTHMA, BINDING, EXPRESSION, CYTOKINES, CELLS, SERUM
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1 +/- 5.0 mU/L) were higher than those of the control group (4.9 +/- 2.1 mU/L) (P <.01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581; P <.01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.