Histopathological efficiency of amifostine in radiation-induced heart disease in rats


Gurses I., Ozeren M., Serin M., Yucel N., Erkal H. S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.119, ss.54-59, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 119 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4149/bll_2018_011
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Sayfa Sayısı: ss.54-59

Özet

OBJECTIVE: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long-term protective effect on heart tissue in an experimental rat model.