Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats


Ayan F., AYTAÇ E., Saygili S., Genc H., Karaca C., Bayrak I., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.22, sa.4, ss.408-413, 2011 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4318/tjg.2011.0189
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.408-413
  • Anahtar Kelimeler: Partial hepatectomy, oxidative stress, lycopene, nitric oxide, NITRIC-OXIDE RELEASE, LIPID-PEROXIDATION, VITAMIN-E, REGENERATION, CAROTENOIDS, METASTASES, HEPATOCYTE, RESECTION, GROWTH, INJURY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background/aims: Partial hepatectomy is performed for the treatment of mass lesions in the liver. Lycopene, which is a carotenoid, is present in various physiologic processes. In this study, the effects of lycopene administration in partially hepatectomized rats were evaluated by assessing various oxidant/antioxidant parameters, remnant liver histology and plasma nitric oxide levels. Methods: Thirty Wistar albino adult male rats were randomly divided into three equal groups as: Sham, Partial Hepatectomy and Lycopene-Administered + Partial Hepatectomy groups. Lycopene (4 mg/kg), which was dissolved in olive oil, was given to the rats per orally (via gavage tube) (0.1 ml) every day for 6 weeks before partial hepatectomy and for one week after partial hepatectomy. Tissue and blood samples were collected one week after partial hepatectomy. Results: Plasma malondialdehyde (p < 0.001) and nitric oxide (p < 0.05) levels in the lycopene-administered + partial hepatectomy group were significantly higher than in the partial hepatectomy group. Intraerythrocytic glutathione (p < 0.001), plasma (p < 0.001) and liver tissue Cu-Zn (p < 0.05) superoxide dismutase levels of the lycopene-administered + partial hepatectomy group were significantly lower than in the partial hepatectomy group. Conclusions:,Lycopene administration could be harmful by increasing oxidative stress after partial hepatectomy.