Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia

AVCU G., Karapinar D. Y., Akinci A. B., Sivis Z. O., Sahin A., Bal Z. S., ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.54, pp.8-12, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijid.2016.10.027
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8-12
  • Keywords: Galactomannan, Aspergillosis, True-positive, False-positive, Children, Acute lymphoblastic leukemia, CELL TRANSPLANT RECIPIENTS, FUNGAL-INFECTIONS, PEDIATRIC-PATIENTS, CANCER, ANTIGENEMIA, REACTIVITY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objectives: Invasive aspergillosis (IA) is an important cause of mortality and morbidity in children with hematological malignancies. The monitoring of serum galactomannan (GM) antigen is considered useful in the diagnosis of IA. The aim of this study was to determine the utility of serum GM monitoring in the early diagnosis of IA and the role of positive antigenemia in the management of children with acute lymphoblastic leukemia (ALL).