Chordoma: Immunohistochemical Analysis of Brachury.

Sun H. I., Güdük M., Gucyetmez B., Yapicier O., Pamir M. N.

Turkish neurosurgery, cilt.28, ss.174-178, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5137/1019-5149.jtn.18587-16.1
  • Dergi Adı: Turkish neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.174-178
  • Anahtar Kelimeler: Chordoma, Brachyury, Microsurgery, Immunohistochemistry, SKULL BASE CHORDOMAS, SURVIVAL PATTERNS, SACRAL CHORDOMA, UNITED-STATES, BRACHYURY, MARKER, TUMORS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

AIM: Chordomas are rare, slow growing but locally aggressive malignancies of the axial skeleton. Skull base chordomas, due to their intricate anatomical localization, pose significant challenges to managing physicians. In classical and chondroid chordomas, the disease course cannot be reliably determined using only morphological criteria. Brachyury (T Gene) was shown to play a central role in chordoma pathogenesis and several studies also showed that this gene also carries potential as a prognostic biomarker. This study aims to correlate Brachyury expression with the clinical course in surgically treated skull base chordomas.