Chordoma: Immunohistochemical Analysis of Brachury.


Sun H. I. , Güdük M. , Gucyetmez B. , Yapicier O., Pamir M. N.

Turkish neurosurgery, vol.28, pp.174-178, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28
  • Publication Date: 2018
  • Doi Number: 10.5137/1019-5149.jtn.18587-16.1
  • Title of Journal : Turkish neurosurgery
  • Page Numbers: pp.174-178

Abstract

AIM: Chordomas are rare, slow growing but locally aggressive malignancies of the axial skeleton. Skull base chordomas, due to their intricate anatomical localization, pose significant challenges to managing physicians. In classical and chondroid chordomas, the disease course cannot be reliably determined using only morphological criteria. Brachyury (T Gene) was shown to play a central role in chordoma pathogenesis and several studies also showed that this gene also carries potential as a prognostic biomarker. This study aims to correlate Brachyury expression with the clinical course in surgically treated skull base chordomas.