Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA

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Dayanc B. E., Bansal S., Gure A. O., Gollnick S. O., Repasky E. A.

INTERNATIONAL JOURNAL OF HYPERTHERMIA, vol.29, no.5, pp.480-490, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/02656736.2013.821526
  • Journal Name: INTERNATIONAL JOURNAL OF HYPERTHERMIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.480-490
  • Keywords: Cytotoxicity, fever-range hyperthermia, HSF-1, MICA, Natural killer cells, NKG2D, CLASS-I MOLECULES, SHOCK FACTOR-I, NKG2D LIGANDS, CHAIN-A, T-LYMPHOCYTES, EPITHELIAL-CELLS, TRANSCRIPTIONAL REGULATION, INHIBITORY RECEPTORS, GENE-TRANSCRIPTION, NK CELLS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Purpose: Previously we showed that mild thermal stress increased natural killer (NK) cell-mediated tumour cytotoxicity and that this could be blocked by anti-NKG2D or anti-MICA (major histolocompatability complex (MHC) class I related chain A) antibodies. Here, we investigated the role of the transcription factor heat shock factor 1 (HSF1) in thermal regulation of MICA expression in tumour cells in vitro and in vivo.