Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA

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Dayanc B. E., Bansal S., Gure A. O., Gollnick S. O., Repasky E. A.

INTERNATIONAL JOURNAL OF HYPERTHERMIA, cilt.29, sa.5, ss.480-490, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/02656736.2013.821526
  • Dergi Adı: INTERNATIONAL JOURNAL OF HYPERTHERMIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.480-490
  • Anahtar Kelimeler: Cytotoxicity, fever-range hyperthermia, HSF-1, MICA, Natural killer cells, NKG2D, CLASS-I MOLECULES, SHOCK FACTOR-I, NKG2D LIGANDS, CHAIN-A, T-LYMPHOCYTES, EPITHELIAL-CELLS, TRANSCRIPTIONAL REGULATION, INHIBITORY RECEPTORS, GENE-TRANSCRIPTION, NK CELLS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: Previously we showed that mild thermal stress increased natural killer (NK) cell-mediated tumour cytotoxicity and that this could be blocked by anti-NKG2D or anti-MICA (major histolocompatability complex (MHC) class I related chain A) antibodies. Here, we investigated the role of the transcription factor heat shock factor 1 (HSF1) in thermal regulation of MICA expression in tumour cells in vitro and in vivo.