Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA


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Dayanc B. E. , Bansal S., Gure A. O. , Gollnick S. O. , Repasky E. A.

INTERNATIONAL JOURNAL OF HYPERTHERMIA, vol.29, no.5, pp.480-490, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/02656736.2013.821526
  • Title of Journal : INTERNATIONAL JOURNAL OF HYPERTHERMIA
  • Page Numbers: pp.480-490

Abstract

Purpose: Previously we showed that mild thermal stress increased natural killer (NK) cell-mediated tumour cytotoxicity and that this could be blocked by anti-NKG2D or anti-MICA (major histolocompatability complex (MHC) class I related chain A) antibodies. Here, we investigated the role of the transcription factor heat shock factor 1 (HSF1) in thermal regulation of MICA expression in tumour cells in vitro and in vivo.