Design of a Gd-DOTA-Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic


Tekdas D. A. , Garifullin R., Senturk B., Zorlu Y., Gundogdu U., Atalar E., ...More

PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol.90, no.6, pp.1376-1386, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1111/php.12332
  • Title of Journal : PHOTOCHEMISTRY AND PHOTOBIOLOGY
  • Page Numbers: pp.1376-1386

Abstract

The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.