Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases.

Sayan M., Şahin B., Mustafayev T., Kefelioğlu E., Vergalasova I., Gupta A., ...More

Neurocirugia (Asturias, Spain), vol.32, pp.261-267, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32
  • Publication Date: 2021
  • Doi Number: 10.1016/j.neucir.2020.08.009
  • Journal Name: Neurocirugia (Asturias, Spain)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.261-267
  • Keywords: Brain metastases, Radiation necrosis, Stereotactic radiosurgery, Whole brain radiation therapy, GAMMA-KNIFE RADIOSURGERY, SINGLE-FRACTION, COMPLICATIONS, RADIONECROSIS, THERAPY, EPIDEMIOLOGY, PROGRESSION, DAMAGE, MODEL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Introduction: Stereotactic radiosurgery (SRS) is a treatment option in the initial management of patients with brain metastases. While its efficacy has been demonstrated in several prior studies, treatment-related complications, particularly symptomatic radiation necrosis (RN), remains as an obstacle for wider implementation of this treatment modality. We thus examined risk factors associated with the development of symptomatic RN in patients treated with SRS for brain metastases.