Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases.


Sayan M., Şahin B., Mustafayev T., Kefelioğlu E., Vergalasova I., Gupta A., ...More

Neurocirugia (Asturias, Spain), vol.32, pp.261-267, 2021 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32
  • Publication Date: 2021
  • Doi Number: 10.1016/j.neucir.2020.08.009
  • Title of Journal : Neurocirugia (Asturias, Spain)
  • Page Numbers: pp.261-267
  • Keywords: Brain metastases, Radiation necrosis, Stereotactic radiosurgery, Whole brain radiation therapy, GAMMA-KNIFE RADIOSURGERY, SINGLE-FRACTION, COMPLICATIONS, RADIONECROSIS, THERAPY, EPIDEMIOLOGY, PROGRESSION, DAMAGE, MODEL

Abstract

Introduction: Stereotactic radiosurgery (SRS) is a treatment option in the initial management of patients with brain metastases. While its efficacy has been demonstrated in several prior studies, treatment-related complications, particularly symptomatic radiation necrosis (RN), remains as an obstacle for wider implementation of this treatment modality. We thus examined risk factors associated with the development of symptomatic RN in patients treated with SRS for brain metastases.