Progressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiency


GÜLER A., GÖKÇAY F., Haznedaroglu D., GÖKÇAY A., Zeytinoglu A., Sagduyu A. , ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.29, no.3, pp.640-644, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2012
  • Title of Journal : JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Page Numbers: pp.640-644

Abstract

Introduction: Progressive Multifocal Leukoencephalopathy(PML) is a rare demyelinating disease of the central nervous system due to reactivation of a latent infection with JC papovavirus. PML predominantly occurs in severely immunosupressed patients, mostly as a late complication of acquired immunodeficiency syndrome and lymphoproliferative disorders. Clinically it is manifested by motor and sensory deficits, ataxia, cognitive impairment and dementia, corresponding to central nervous system (CNS) lesions. It is difficult to distinguish PML clinically from immune-mediated diseases of the CNS, such as multiple sclerosis, neuropsychiatric sistemic lupus erythematosus and CNS vasculitis.