Amygdala kindling in the WAG/Rij rat model of absence epilepsy


GÜLHAN R., YANANLI H. R. , Gurbanova A., Ozkaynakci A., Ates N., van Luijtelaar G., ...More

EPILEPSIA, vol.47, no.1, pp.33-40, 2006 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1528-1167.2006.00367.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-40
  • Keywords: absence epilepsy rats, spike-and-wave discharge, generalized epilepsy, partial epilepsy, convulsion, GAERS, SPIKE-WAVE DISCHARGES, ELECTRICAL-STIMULATION, SEIZURES, COEXISTENCE, EXCITATION, THALAMUS, NEURONS, STRAIN, CA1
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Purpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved in the propagation and generalization of seizure activity in the convulsive and nonconvulsive components of epilepsy. In the present study, we compared the amygdala kindling rate and afterdischarge characteristics of the nonepileptic Wistar control rat with a well-validated model of absence epilepsy, the WAG/Rij rat, and demonstrated the effect of amygdala kindling on spike-and-wave discharges (SWDs) in the WAG/Rij group.