Amygdala kindling in the WAG/Rij rat model of absence epilepsy


GÜLHAN R., YANANLI H. R. , Gurbanova A., Ozkaynakci A., Ates N., van Luijtelaar G., ...Daha Fazla

EPILEPSIA, cilt.47, sa.1, ss.33-40, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Konu: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1528-1167.2006.00367.x
  • Dergi Adı: EPILEPSIA
  • Sayfa Sayıları: ss.33-40

Özet

Purpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved in the propagation and generalization of seizure activity in the convulsive and nonconvulsive components of epilepsy. In the present study, we compared the amygdala kindling rate and afterdischarge characteristics of the nonepileptic Wistar control rat with a well-validated model of absence epilepsy, the WAG/Rij rat, and demonstrated the effect of amygdala kindling on spike-and-wave discharges (SWDs) in the WAG/Rij group.