Survival by self-destruction: a role for autophagy in the placenta?


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Bildirici İ. , Longtine M. S. , Chen B., Nelson D. M.

Placenta, vol.33, no.8, pp.591-8, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 8
  • Publication Date: 2012
  • Doi Number: 10.1016/j.placenta.2012.04.011
  • Title of Journal : Placenta
  • Page Numbers: pp.591-8
  • Keywords: Placenta, Trophoblast, Autophagy, Apoptosis, mTOR, ATG genes, CASPASE-MEDIATED CLEAVAGE, HYPOXIA-INDUCED AUTOPHAGY, ACTIVATED PROTEIN-KINASE, BCL-X-L, CELL-DEATH, OXIDATIVE STRESS, TUMOR-SUPPRESSOR, MAMMALIAN TARGET, DUAL ROLE, JNK1-MEDIATED PHOSPHORYLATION

Abstract

Autophagy is a burgeoning area of research from yeast to humans. Although previously described as a death pathway, autophagy is now considered an important survival phenomenon in response to environmental stressors to which most organs are exposed.