Molecular modeling and antimycobacterial studies of Mannich bases: 5-hydroxy-2-methyl-4H-pyran-4-ones

Berk B., Us D., Oktem S., KOCAGÖZ Z. T., Caglayan B., KURNAZ I., ...Daha Fazla

TURKISH JOURNAL OF CHEMISTRY, cilt.35, sa.2, ss.317-330, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3906/kim-1006-689
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.317-330
  • Anahtar Kelimeler: Antimycobacterial activity, DNA gyrase activity, hydroxy-4H-pyran-4-one, homology modeling, DNA-GYRASE, KOJIC ACID, TOPOISOMERASE-IV, CRYSTAL-STRUCTURE, DERIVATIVES, INHIBITORS, BINDING, TARGET, CONFORMATION, NOVOBIOCIN
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

The World Health Organization lists tuberculosis among the top 3 leading causes of death from a single infectious agent, and reported cases of multidrug-resistant tuberculosis (MDR-TB) are on the rise.