REGULATION OF THE EUKARYOTIC PROTEIN-SYNTHESIS BY PHOSPHORYLATION OF ELONGATION FACTOR-II

ERDOGDU G., CIRAKOGLU B., KAN B.

BIOCHEMICAL ARCHIVES, cilt.9, sa.2, ss.91-99, 1993 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 1993
  • Dergi Adı: BIOCHEMICAL ARCHIVES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.91-99
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The phosphorylation of elongation factor 2 (EF-2) by Ca2+/calmodulin kinase III decreases its activity and results in inhibition of translation. The effects of different experimental conditions on the phosphorylation of EF-2 in rabbit reticulocyte have been investigated. The phosphorylation of EF-2 was enhanced in the presence of GDP and inhibited by cyclic-AMP and NEM whereas the ADP-ribosylation of EF-2 did not change the extent of its phosphorylation.