Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats


Aydin A. F. , Kucukgergin C., Bingul I., Dogan-Ekici I. , Dogru-Abbasoglu S., Uysal M.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.125, no.5, pp.282-289, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0043-100117
  • Title of Journal : EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Page Numbers: pp.282-289
  • Keywords: carnosine, high fat diet, streptozotocin, oxidative stress, advanced glycation end products, renal function, CARBONYL STRESS, LEUCINE REPEAT, NEPHROPATHY, DIET, DISEASE, INJURY, SUPPLEMENTATION, TISSUES, DAMAGE, ASSAY

Abstract

Background High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role in the development of diabetic complications. Carnosine (CAR) has antioxidant and antiglycating properties. We investigated effects of CAR on renal function, oxidation and glycation products in HFD + STZ-rats.