Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats

AYDIN A. F., KÜÇÜKGERGİN C., BİNGÜL İ., Dogan-Ekici I., ABBASOĞLU S., Uysal M.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.125, no.5, pp.282-289, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0043-100117
  • Journal Name: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.282-289
  • Keywords: carnosine, high fat diet, streptozotocin, oxidative stress, advanced glycation end products, renal function, CARBONYL STRESS, LEUCINE REPEAT, NEPHROPATHY, DIET, DISEASE, INJURY, SUPPLEMENTATION, TISSUES, DAMAGE, ASSAY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role in the development of diabetic complications. Carnosine (CAR) has antioxidant and antiglycating properties. We investigated effects of CAR on renal function, oxidation and glycation products in HFD + STZ-rats.