Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats


Aydin A. F. , Kucukgergin C., Bingul I., Dogan-Ekici I. , Dogru-Abbasoglu S., Uysal M.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.125, no.5, pp.282-289, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0043-100117
  • Title of Journal : EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Page Numbers: pp.282-289

Abstract

Background High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role in the development of diabetic complications. Carnosine (CAR) has antioxidant and antiglycating properties. We investigated effects of CAR on renal function, oxidation and glycation products in HFD + STZ-rats.