Öztürk Ö., İnan M. A., Akalın M., Sahin M. M., Celtikci E.
JOURNAL OF NEUROLOGICAL SURGERY REPORTS, cilt.86, sa.04, ss.245-248, 2025 (ESCI)
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Yayın Türü:
Makale / Vaka Takdimi
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Cilt numarası:
86
Sayı:
04
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Basım Tarihi:
2025
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Doi Numarası:
10.1055/a-2753-9561
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Dergi Adı:
JOURNAL OF NEUROLOGICAL SURGERY REPORTS
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Derginin Tarandığı İndeksler:
Emerging Sources Citation Index (ESCI), EMBASE, Directory of Open Access Journals
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Sayfa Sayıları:
ss.245-248
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Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli:
Evet
Özet
Gangliocytomas of the sellar region are rare, well-differentiated, benign tumors that may coexist with pituitary adenomas, forming so-called “collision tumors.” These lesions often present with endocrine dysfunction, most commonly acromegaly.
We report a 69-year-old female who presented with drug-resistant headaches, acromegalic features, and signs of Cushing's disease. Magnetic resonance imaging showed a sellar mass with extension into the clivus. Endoscopic transsphenoidal resection revealed a tumor composed of ganglion cells and adenohypophyseal components. Immunohistochemistry confirmed a diagnosis of gangliocytoma coexisting with a hormone-secreting pituitary adenoma. Postoperative hormonal normalization was achieved.
Sellar gangliocytomas with dual hormonal activity pose diagnostic challenges and highlight the importance of histological and immunohistochemical evaluation. Awareness of these rare entities can prevent misdiagnosis and support appropriate surgical management.