Effects of Nasal CPAP Treatment on Insulin Resistance, Lipid Profile, and Plasma Leptin in Sleep Apnea

Cuhadaroglu Ç., Utkusavas A., Oeztuerk L., Salman S., Ece T.

LUNG, vol.187, no.2, pp.75-81, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 187 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s00408-008-9131-5
  • Journal Name: LUNG
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.75-81
  • Keywords: Sleep apnea, Leptin, Insulin resistance, Continuous positive airway pressure, Lipid, POSITIVE AIRWAY PRESSURE, METABOLIC SYNDROME, VISCERAL OBESITY, SENSITIVITY, DISEASE, FAT, ASSOCIATION, SEVERITY, GENDER, ADULTS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Background Obstructive sleep apnea has been linked with metabolic syndrome characterized by dyslipidemia, dyscoagulation, hypertension, and diabetes mellitus type 2 and their cardiovascular consequences. This study was designed to determine the effects of 8 weeks of therapy with continuous positive airway pressure (CPAP) on insulin resistance, glucose, and lipid profile, and the relationship between leptin and insulin-resistance parameters in patients with moderate-to-severe obstructive sleep apnea.