Effects of Nasal CPAP Treatment on Insulin Resistance, Lipid Profile, and Plasma Leptin in Sleep Apnea

Cuhadaroglu Ç. , Utkusavas A., Oeztuerk L., Salman S., Ece T.

LUNG, vol.187, no.2, pp.75-81, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 187 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s00408-008-9131-5
  • Title of Journal : LUNG
  • Page Numbers: pp.75-81
  • Keywords: Sleep apnea, Leptin, Insulin resistance, Continuous positive airway pressure, Lipid, POSITIVE AIRWAY PRESSURE, METABOLIC SYNDROME, VISCERAL OBESITY, SENSITIVITY, DISEASE, FAT, ASSOCIATION, SEVERITY, GENDER, ADULTS


Background Obstructive sleep apnea has been linked with metabolic syndrome characterized by dyslipidemia, dyscoagulation, hypertension, and diabetes mellitus type 2 and their cardiovascular consequences. This study was designed to determine the effects of 8 weeks of therapy with continuous positive airway pressure (CPAP) on insulin resistance, glucose, and lipid profile, and the relationship between leptin and insulin-resistance parameters in patients with moderate-to-severe obstructive sleep apnea.