Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review

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Bongiovanni M., Mermod M., Canberk S., Saglietti C., Sykiotis G. P. , Pusztaszeri M., ...More

CANCER CYTOPATHOLOGY, vol.125, no.6, pp.389-397, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 125 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1002/cncy.21860
  • Title of Journal : CANCER CYTOPATHOLOGY
  • Page Numbers: pp.389-397


BACKGROUNDThe columnar cell variant of papillary thyroid carcinoma (PTC-CCV) is a rare entity that demonstrates a more aggressive clinical course compared with the more common subtypes of PTC. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Because to the authors' knowledge no characteristic cytomorphological features have been identified to date and typical features of PTC often are absent on cytology, the diagnosis of PTC-CCV by fine-needle aspiration (FNA) is challenging. This prompted the authors to evaluate a series of PTC-CCV cases to identify features that could facilitate its diagnosis by FNA.