High GRP78 levels in Covid-19 infection: A case-control study

Sabirli R., KÖSELER A., Goren T., TÜRKÇÜER İ., KURT Ö.

LIFE SCIENCES, vol.265, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 265
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2020.118781
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Endoplasmic reticulum stress, GRP78, Covid-19 infection, Pneumonia, ENDOPLASMIC-RETICULUM STRESS, CORONAVIRUS, PROTEIN, SEVERITY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Introduction: Covid-19 infection was declared a global pandemic by WHO on March 11, 2020. GRP78 protein is known to be involved in the intrusion of numerous viruses. Our current study tries to provide some insight into the variation of GRP78 protein levels in patients with Covid-19 (-) pneumonia, Covid-19 (+) pneumonia, and CT negative Covid-19 infection in comparison to the normal population through a larger number of cases.