Increased expression of exon 2 deleted MEFV transcript in familial Mediterranean fever patients


Kirectepe A. K. , Erdem G. C. , Senturk N., Arisoy N., Hatemi G., Ozdogan H., ...More

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, vol.38, no.4, pp.327-329, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1744-313x.2011.01015.x
  • Title of Journal : INTERNATIONAL JOURNAL OF IMMUNOGENETICS
  • Page Numbers: pp.327-329

Abstract

A defect in MEFV gene expression regulation has been implicated in familial Mediterranean fever (FMF) etiopathophysiology. Here we show significantly higher expression level in second exon lacking MEFV transcript in FMF patients compared with healthy controls (P = 0.026). Our results also point out a possible role of exon 2 deleted MEFV transcript in FMF pathogenesis.