Akademik Veri Yönetim Sistemi
CYPRUS JOURNAL OF MEDICAL SCIENCES, sa.4, ss.289-296, 2024 (ESCI)
BACKGROUND/AIMS: Endocervical adenocarcinoma (ECA) accounts for 25% of cervical cancers and is clinically more aggressive than squamous cell carcinoma (SCC). Similarly, SCC and ECA can be treated without the formation of invasive tumors if precursor lesions are identified and treated accordingly. The objective of this study is to analyze the effectiveness of screening tests in the detection of endocervical adenocarcinoma in situ (AIS), which represents a precursor lesion of ECA. MATERIALS AND METHODS: The study comprised a total of 121 cases, including 83 cases of ECA and 38 cases of AIS, diagnosed through histopathologically examination between 2020 and 2023 at our center. The clinical history, cytological findings, results of the high-risk human papillomavirus (hrHPV) test, and other pathological findings from the pathology reports of the patients aged 26 to 84 years were subjected to RESULTS: A total of 22.2% of the cervical carcinoma cases diagnosed histopathologically at our center during the study period were ECA. The mean age of the ECA cases was 48.6 years while that of the AIS cases was 39 years. A positive association was observed between HPV and 94% of ECA cases. Among the 83 ECA cases, 56.6% had not undergone screening, and 88% had not undergone an hrHPV test. A total of 33 patients with AIS underwent a screening test, and 31 cases exhibited abnormalities in the smear. All 13 AIS cases that underwent hrHPV screening tested positive for hrHPV. A biopsy was performed in 33 of the 38 AIS cases based on the combined evaluation of the PAP smear and the hrHPV test results. CONCLUSION: Our study emphasizes the effectiveness of the combined PAP smear and hrHPV screening tests in the early detection of ECA at the AIS stage, achieving a success rate of 96.9%.