Aim: The effects of esmolol infusion on perioperative haemodynamic parameters, total amounts of fentanyl used and recovery were investigated in patients who experienced craniotomies. Material and Method: Forty cases were randomized into two groups as esmolol and control groups. In the esmolol group, patients received esmolol at a loading dose of 500 μg/kg, and then as an infusion at a rate of 100 μg/kg/min. Five minutes after the extubation, esmolol infusion was stopped. During the operation fentanyl infusion were administered at doses of 0.015-0.05 μg/kg/min so as to maintain targeted mean arterial pressure at 90-110 mmHg Mean arterial pressures and heart rates, total amounts of fentanyl used, the number of changes in fentanyl infusion rates, and time to reach an Aldrete recovery score of 9 were recorded. Results: In the esmolol group, heart rates and mean arterial pressures were maintained better during the perioperative period. In the esmolol group total amount of fentanyl used and the number of changes in fentanyl infusion rates decreased significantly, and the time to reach an Aldrete recovery score of 9 was significantly more prolonged relative to the control group. Conclusion: It was concluded that esmolol infusion is a safe and useful method in patients undergoing craniotomies. regarding maintenance of hemodynamic stability, reduction of total fentanyl dose used and achievement of an earlier postoperative recovery.