Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

TOPKAYA TAŞKIRAN D., Lafont D., Poyer F., Garcia G., Albrieux F., Maillard P., ...More

NEW JOURNAL OF CHEMISTRY, vol.40, no.3, pp.2044-2050, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1039/c5nj02716k
  • Journal Name: NEW JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2044-2050
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.