Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

TOPKAYA TAŞKIRAN D., Lafont D., Poyer F., Garcia G., Albrieux F., Maillard P., ...Daha Fazla

NEW JOURNAL OF CHEMISTRY, cilt.40, sa.3, ss.2044-2050, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c5nj02716k
  • Dergi Adı: NEW JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2044-2050
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.