Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

Topkaya D., Lafont D., Poyer F., Garcia G., Albrieux F., Maillard P., ...More

NEW JOURNAL OF CHEMISTRY, vol.40, no.3, pp.2044-2050, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1039/c5nj02716k
  • Title of Journal : NEW JOURNAL OF CHEMISTRY
  • Page Numbers: pp.2044-2050


A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.