Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity


Topkaya D., Lafont D., Poyer F., Garcia G., Albrieux F., Maillard P., ...Daha Fazla

NEW JOURNAL OF CHEMISTRY, cilt.40, ss.2044-2050, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c5nj02716k
  • Dergi Adı: NEW JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.2044-2050

Özet

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.