Is there any difference between primary systemic treatment and surgery in terms of early period complication for patients underwent nipple sparing mastectomy: a preliminary assessment?

Arikan A. E.

5th International Conference on Multidisciplinary Studies in Health Sciences, Ankara, Türkiye, 23 - 25 Eylül 2022, ss.1

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.1
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Surgeons dealing with treatment of breast cancer, mostly accuse primary systemic treatment for complications in early-period after nipple sparing mastectomy followed by immediate implant-based reconstruction. This study is a preliminary assessment for existence of this kind relation.

Database of Acibadem University, Research Institute of Senology was queried for patients who underwent nipple sparing mastectomy with immediate implant-based reconstruction between 2019 April and 2021 December for invasive ductal carcinoma (either with or without in-situ component) with data for complication was recorded. Male patients and patients with history of previous breast cancer were excluded.

Fifty-four breasts were eligible for preliminary assessment in dataset of 1344 records. All records were grouped as primary surgery (Group Sx) and neoadjuvant treatment before surgery (Group Ps). All outcomes and possible predictors were compared between these groups. Continues variables were analyzed with student’s t test and categorical variables are analyzed with chi-square test and Fisher’s exact test if required.

There were 27 (50%) record in Group Sx and 27 (50%) in Group Ps. There was no difference between groups in terms of age (43.7±8.1 vs 43.6±8.2, p=0.96) contrary to initial tumor size (27.3±13.1 vs 34.96±13.3, p=0.04). In comparison of early complications there was no statistical difference (for both n=4, 14.8%, p=1), similar to late complications (for both n=3, 11.1%, p=1) and any type of complications (n=3, 11.1% for Group Sx and n=4, 14.8% for group Ps, p=0.76). none of the complications was life-threatening according to Clavien-Dindo classification. When complications were compared as Grade I vs greater and Grade II vs greater according Clavien-Dindo classification there were no statistical difference (p=1 and p= 0.57)

In terms of complication, either early or late post-operative period, there were no difference between primary systemic treatment and primary surgery for patients with breast cancer.