EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors

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Kothmaier H., Quehenberger F., Halbwedl I., Morbini P., Demirag F., Zeren H., ...More

THORAX, vol.63, no.4, pp.345-351, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1136/thx.2007.085241
  • Journal Name: THORAX
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.345-351
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: Malignant pleural mesothelioma (MPM) is an asbestos related tumour difficult to detect early and treat effectively. Asbestos causes genetic modifications and cell signalling events that favour the resistance of MPM to apoptosis and chemotherapy. Only a small number of patients, approximately 10%, survive more than 3 years. The aim of our study was to assess possible differences within signalling pathways between short term survivors (survival <3 years; STS) and long term survivors (survival >3 years; LTS) of MPM.