Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells


Cihan Üstündağ G., Somuncu B., Müftüoğlu M. , Karalı L. N.

JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY, vol.51, pp.161-166, 2021 (National Refreed University Journal) identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.876788
  • Title of Journal : JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY
  • Page Numbers: pp.161-166
  • Keywords: Indomethacin, acemetacin, tromethamine, HCT116, anti-cancer, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ANTITUMOR-ACTIVITY, MECHANISMS, CARCINOMA, APOPTOSIS, NSAIDS

Abstract

Background and Aims: Since 1980's, several preclinical studies have been published on the anti-colorectal cancer activity of the nonsteroidal anti-inflammatory drug indomethacin. The direct anti-proliferative effect of indomethacin seems to occur via a variety of reported COX-independent mechanisms. Acemetacin is a glycolic acid ester derivative of indomethacin and contrary to indomethacin, there is not much published research on anti-cancer effects of acemetacin. Herein, we compared the in vitro anti-proliferative properties of indomethacin, acemetacin, and their tromethamine salts in HCT116 colon cancer cells.