Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells
JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY, cilt.51, ss.161-166, 2021 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51
- Basım Tarihi: 2021
- Doi Numarası: 10.26650/istanbuljpharm.2021.876788
- Dergi Adı: JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.161-166
- Anahtar Kelimeler: Indomethacin, acemetacin, tromethamine, HCT116, anti-cancer, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ANTITUMOR-ACTIVITY, MECHANISMS, CARCINOMA, APOPTOSIS, NSAIDS
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Background and Aims: Since 1980's, several preclinical studies have been published on the anti-colorectal cancer activity of the nonsteroidal anti-inflammatory drug indomethacin. The direct anti-proliferative effect of indomethacin seems to occur via a variety of reported COX-independent mechanisms. Acemetacin is a glycolic acid ester derivative of indomethacin and contrary to indomethacin, there is not much published research on anti-cancer effects of acemetacin. Herein, we compared the in vitro anti-proliferative properties of indomethacin, acemetacin, and their tromethamine salts in HCT116 colon cancer cells.