Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells

Cihan Üstündağ G., Somuncu B., Müftüoğlu M., Karalı L. N.

JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY, vol.51, pp.161-166, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.876788
  • Journal Name: JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.161-166
  • Keywords: Indomethacin, acemetacin, tromethamine, HCT116, anti-cancer, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ANTITUMOR-ACTIVITY, MECHANISMS, CARCINOMA, APOPTOSIS, NSAIDS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background and Aims: Since 1980's, several preclinical studies have been published on the anti-colorectal cancer activity of the nonsteroidal anti-inflammatory drug indomethacin. The direct anti-proliferative effect of indomethacin seems to occur via a variety of reported COX-independent mechanisms. Acemetacin is a glycolic acid ester derivative of indomethacin and contrary to indomethacin, there is not much published research on anti-cancer effects of acemetacin. Herein, we compared the in vitro anti-proliferative properties of indomethacin, acemetacin, and their tromethamine salts in HCT116 colon cancer cells.