Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury


Caner B., Kafa M. I. , BEKAR A., Kurt M. A. , Karli N., CANSEV M., et al.

NEUROLOGICAL RESEARCH, cilt.34, ss.238-245, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1179/1743132812y.0000000003
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Sayfa Sayısı: ss.238-245

Özet

Objective: Topical cytidine-5'-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its beneficial actions.