Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury


Caner B., Kafa M. I. , BEKAR A., Kurt M. A. , Karli N., CANSEV M., ...More

NEUROLOGICAL RESEARCH, vol.34, no.3, pp.238-245, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1179/1743132812y.0000000003
  • Title of Journal : NEUROLOGICAL RESEARCH
  • Page Numbers: pp.238-245

Abstract

Objective: Topical cytidine-5'-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its beneficial actions.