Exposure to Perchlorate in Lactating Women and Its Associations With Newborn Thyroid Stimulating Hormone

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Uçal Y., Sahin O. N., Serdar M. A., Blount B., Kumru P., Muhcu M., ...Daha Fazla

FRONTIERS IN ENDOCRINOLOGY, cilt.9, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3389/fendo.2018.00348
  • Dergi Adı: FRONTIERS IN ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: NIS inhibitors, perchlorate, nitrate, thiocyanate, colostrum, newborn thyroid health, SODIUM-IODIDE SYMPORTER, BOSTON-AREA WOMEN, PREGNANT-WOMEN, DRINKING-WATER, BREAST-MILK, THIOCYANATE, NITRATE, CALIFORNIA, ORIGIN, NIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Perchlorate, thiocyanate, and nitrate can block iodide transport at the sodium iodide symporter (NIS) and this can subsequently lead to decreased thyroid hormone production and hypothyroidism. NIS inhibitor exposure has been shown to reduce iodide uptake and thyroid hormone levels; therefore we hypothesized that maternal NIS inhibitor exposure will influence both maternal and newborn thyroid function.