Akademik Veri Yönetim Sistemi
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.9, sa.1, ss.4-10, 2003 (Scopus)
The aim of this study was to investigate, the early term changes in intraabdominal "systemic inflammatory response syndrome" (SIRS) model in rabbits which were ventilated with lung protective mechanical ventilation. After the ketamine sedation, ear vein and arteria of the 24 New Zealand rabbits were cannulated. Rabbits were randomly divided into three groups (n:8). Group 1 (control group) was without laparotomy and SIRS. In group 2, laparotomy was performed, cecums were tied, punctured once and intraabdominal catheter was inserted for intraabdominal pressure (IAP) monitorization. In group 3, only laparotomy was performed and catheter was inserted. Tracheostomy was performed one hour later and animals were ventilated for 3 hours with lung protective mechanical ventilation. IAP, airway pressures (Ppeak, Ppause, Pmean), compliance and hemodynamic parameters were recorded at every hour. Samples for arterial blood gases analysis were taken at the beginning of the mechanical ventilation, at the 90th minutes and at the end of the study. At the end of the study the left lungs of all rabbits were removed for histopathological examination. Ppeak values were higher in group 3 at 60th and 180th min recordings than the group 1, and in group 2, 180th min values were higher than the group 1 (p<0.05). At the beginning of the mechanical ventilation PaO2 values were lower in group 2 than the group 1 (p<0.01). In groups 2 and 3, HCO3 and pH values were lower than the group 1 (p<0.01) at 90th, 180th min, and in group 3 HCO3 values were higher at 90th and 180th min than the group 2 (p<0.01). In the view of the histopathological examination, in group 2 bronchial epithelial injury, edema, atelectasis and hemorrhage were higher than group 1 and 3 (p<0.01). To our concern, the increase in intraabdominal and airway pressure parallel to the decrease in lung compliance and accompanying histopathological changes may be the initial signs of acute lung injury although there are no significant differences in PaO2 values and hemodynamic parameters in the early term of SIRS.