Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)


Sayitoglu M., Erbilgin Y., Ng Ö. , Yildiz I., Celkan T., Anak S., et al.

TURKISH JOURNAL OF HEMATOLOGY, cilt.29, ss.325-333, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 29 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5505/tjh.2012.13540
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Sayfa Sayısı: ss.325-333

Özet

Objective: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations and abnormal ectopic gene expression during T-cell development. In order to gain insight into the pathogenesis of T-ALL this study aimed to measure the level of expression of 7 T-cell oncogenes (LMO2, LYL1, TAL1, TLX1, TLX3, BMI1, and CALM-AF10) in pediatric T-ALL patients.