Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

SAYİTOĞLU M., ERBİLGİN Y., HATIRNAZ NG Ö., Yildiz I., Celkan T., Anak S., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.29, no.4, pp.325-333, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5505/tjh.2012.13540
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.325-333
  • Keywords: T-ALL, Pediatric, Transcription factor, Expression, Prognosis, MOLECULAR PATHOGENESIS, HOX11L2 EXPRESSION, RECEPTOR GENE, MUTATIONS, NOTCH1, TLX1
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objective: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations and abnormal ectopic gene expression during T-cell development. In order to gain insight into the pathogenesis of T-ALL this study aimed to measure the level of expression of 7 T-cell oncogenes (LMO2, LYL1, TAL1, TLX1, TLX3, BMI1, and CALM-AF10) in pediatric T-ALL patients.