Impact of Neuro-Behcet Disease Immunoglobulin G on Neuronal Apoptosis

GİRİŞ M., Bireller S., KÜÇÜKALİ C. İ., Hanagasi H., Degirmencioglu S., TÜZÜN E.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.54, no.1, pp.67-71, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5152/npa.2016.19421
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.67-71
  • Keywords: Behcet disease, neuro-Behcet disease, immunoglobulin G, terminal deoxynucleotidyl transferase dUTP nick end labeling, neurotoxicity, NEUROLOGICAL INVOLVEMENT, ANTIBODIES, FEATURES, STRESS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Introduction: Parenchymal neuro-Behcet disease (NBD) is encountered in 5%-15% of Behcet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures. Neuronal apoptosis has been shown to participate in neuronal cell loss. Anti-neuronal antibodies have been identified in NBD patients. However, the pathogenic properties of these antibodies have not been studied.