Akademik Veri Yönetim Sistemi
FRONTIERS IN MEDICINE, 2023 (SCI-Expanded)
BackgroundOxidative stress plays an important role in the pathogenesis of many diseases. This study aimed to investigate the relationship between nuclear factor kappa B (NF-kappa B) and oxidative stress and the severity of the disease in new COVID-19 patients, and, to compare the levels of NF-kappa B, oxidized LDL (oxLDL), and lectin-like oxidized-LDL receptor-1 (LOX-1) with oxygen saturation, which is an indicator of the severity parameters of the disease in COVID-19 patients. MethodsIn this prospective study, 100 COVID-19 patients and 100 healthy subjects were selected. ResultsLOX-1, NF-kappa B, and oxLDL were found to be higher in COVID-19 patients compared to the healthy subjects (p < 0.001 for all). According to the results of correlation analysis, it was found that there was no significant relationship between oxygen saturation and LOX-1, NF-kappa B and oxLDL parameters. There was significant relationship between oxLDL with LOX-1 and NF-kappa B in patients with COVID-19 disease. ROC analysis results of the highest discrimination power were oxLDL (AUC: 0.955, CI: 0.904-1.000; sensitivity: 77%, and specificity: 100%, for cutoff: 127.944 ng/l) indicating COVID-19. ConclusionOxidative stress plays an essential role in COVID-19. NF-kappa B, oxLDL, and LOX-1 seem to represent good markers in COVID-19. Our study also showed that oxLDL has the highest power in distinguishing patients with COVID-19 from the healthy subjects.