Orexins increase penicillin-induced epileptic activity


Kortunay S., Erken H. A., Erken G., Genc O., Sahiner M., TURGUT S., ...More

PEPTIDES, vol.34, no.2, pp.419-422, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.peptides.2012.02.013
  • Journal Name: PEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.419-422
  • Keywords: EEG, Epilepsy, Orexin, Penicillin, Power spectrum, Seizure, RAT-BRAIN, LOCUS-COERULEUS, NEURONS, NUCLEUS, OREXIN/HYPOCRETIN, HYPOCRETIN-1, RELEASE, DEPOLARIZES, PEPTIDES, SEIZURES
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G. (C) 2012 Elsevier Inc. All rights reserved.