Orexins increase penicillin-induced epileptic activity

Kortunay S., Erken H. A., Erken G., Genc O., Sahiner M., TURGUT S., ...Daha Fazla

PEPTIDES, cilt.34, sa.2, ss.419-422, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.peptides.2012.02.013
  • Dergi Adı: PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-422
  • Anahtar Kelimeler: EEG, Epilepsy, Orexin, Penicillin, Power spectrum, Seizure, RAT-BRAIN, LOCUS-COERULEUS, NEURONS, NUCLEUS, OREXIN/HYPOCRETIN, HYPOCRETIN-1, RELEASE, DEPOLARIZES, PEPTIDES, SEIZURES
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G. (C) 2012 Elsevier Inc. All rights reserved.