Pancreatic Neuropathy Results in " Neural Remodeling " and Altered Pancreatic Innervation in Chronic Pancreatitis and Pancreatic Cancer

Ceyhan G., Demir I. E., Rauch U., Bergmann F., Mueller M. W., Buechler M. W., ...More

AMERICAN JOURNAL OF GASTROENTEROLOGY, vol.104, no.10, pp.2555-2565, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 10
  • Publication Date: 2009
  • Doi Number: 10.1038/ajg.2009.380
  • Journal Name: AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.2555-2565
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

OBJECTIVES: Chronic pancreatitis (CP) and pancreatic cancer (PCa) are characterized by intrapancreatic neuropathic alterations, including increased neural density and hypertrophy, pancreatic neuritis and neural invasion (NI) by cancer cells in PCa. The aim of this study was to identify the influence of these neuropathic changes on the quality of pancreatic innervation, intrapancreatic glia, and visceral pain.