The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma


Altas M., Bayrak O. F. , Ayan E., Bolukbasi F., Silav G., Coskun K. K. , ...More

ACTA NEUROCHIRURGICA, vol.152, no.9, pp.1611-1617, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.1007/s00701-010-0671-0
  • Title of Journal : ACTA NEUROCHIRURGICA
  • Page Numbers: pp.1611-1617

Abstract

The matrix metalloproteinase-1 enzyme (MMP-1, also called collagenase 1) plays a key role in turnover of collagen fibers in the intercellular matrix. Insertion of a guanine residue was found within the promoter region of the MMP-1 gene. We found that MMP-1 levels increased approximately twofold over normal when this insertion was present, enabling MMP-1 to facilitate tumor invasion and metastasis. MMP-1 is also believed to play a role in tumor development. The aim of our study is to investigate the effect of polymorphisms in the promoter region of the MMP-1 gene on the development of benign and invasive hypophyseal adenomas.