Cytochrome c oxidase deficiency in a child with isolated myopathy


Karadag A., Avci Z., Catal F., Odemis E.

FETAL AND PEDIATRIC PATHOLOGY, vol.24, no.3, pp.149-153, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1080/15227950500304218
  • Title of Journal : FETAL AND PEDIATRIC PATHOLOGY
  • Page Numbers: pp.149-153

Abstract

Cytochrome c oxidase ( COX) deficiency is the most commonly recognized respiratory chain defect in childhood. The disease is clinically heterogeneous with phenotypes including Leigh syndrome, hepatic failure and myopathies. COX deficiency has been associated with mitochondrial DNA mutations in COX I, II, and III with large- scale deletions of the mitochondrial genome and with point mutations in mitochondrial tRNA genes. Here we report on a 3.5- year- old girl with a rare type of isolated myopathy due to COX deficiency.