Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

Belykh, Evgenii; Miller, Eric; Patel, Arpan; Yazdanabadi, Mohammedhassan; Martirosyan, Nikolay; Yagmurlu, Kaan; Bozkurt, BARAN; Byvaltsev, Vadim; Eschbacher, Jennifer; Nakaji, Peter; Preul, Mark

doi:10.1016/j.wneu.2018.04.048

Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

Atıf İçin Kopyala

Belykh E., Miller E. J., Patel A. A., Yazdanabadi M. L., Martirosyan N. L., Yagmurlu K., ...Daha Fazla

WORLD NEUROSURGERY, cilt.115, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 115
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.wneu.2018.04.048
Dergi Adı: WORLD NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Bloodebrain-barrier, Confocal endomicroscopy, Fluorescein sodium, Fluorescence-guided resection, Glioma, Tumor, HIGH-GRADE GLIOMAS, SURGICAL MICROSCOPE FILTER, LOW-COST DEVICE, BRAIN-TUMORS, 5-AMINOLEVULINIC ACID, SODIUM FLUORESCEIN, ANEURYSM SURGERY, BLOOD-FLOW, GUIDANCE, MODEL
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from nontumor areas with a compromised bloode-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor tissue in an animal glioma model.