Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

Belykh, Evgenii; Miller, Eric; Patel, Arpan; Yazdanabadi, Mohammedhassan; Martirosyan, Nikolay; Yagmurlu, Kaan; Bozkurt, BARAN; Byvaltsev, Vadim; Eschbacher, Jennifer; Nakaji, Peter; Preul, Mark

doi:10.1016/j.wneu.2018.04.048

Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

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Belykh E., Miller E. J. , Patel A. A. , Yazdanabadi M. L. , Martirosyan N. L. , Yagmurlu K., ...More

WORLD NEUROSURGERY, vol.115, 2018 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 115
Publication Date: 2018
Doi Number: 10.1016/j.wneu.2018.04.048
Title of Journal : WORLD NEUROSURGERY

Abstract

OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from nontumor areas with a compromised bloode-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor tissue in an animal glioma model.