WORLD NEUROSURGERY, vol.115, 2018 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Bloodebrain-barrier, Confocal endomicroscopy, Fluorescein sodium, Fluorescence-guided resection, Glioma, Tumor, HIGH-GRADE GLIOMAS, SURGICAL MICROSCOPE FILTER, LOW-COST DEVICE, BRAIN-TUMORS, 5-AMINOLEVULINIC ACID, SODIUM FLUORESCEIN, ANEURYSM SURGERY, BLOOD-FLOW, GUIDANCE, MODEL
OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from nontumor areas with a compromised bloode-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor tissue in an animal glioma model.