Diagnostic Accuracy of a Confocal Laser Endomicroscope for In Vivo Differentiation Between Normal Injured And Tumor Tissue During Fluorescein-Guided Glioma Resection: Laboratory Investigation

Belykh E., Miller E. J. , Patel A. A. , Yazdanabadi M. L. , Martirosyan N. L. , Yagmurlu K., ...More

WORLD NEUROSURGERY, vol.115, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 115
  • Publication Date: 2018
  • Doi Number: 10.1016/j.wneu.2018.04.048
  • Title of Journal : WORLD NEUROSURGERY
  • Keywords: Bloodebrain-barrier, Confocal endomicroscopy, Fluorescein sodium, Fluorescence-guided resection, Glioma, Tumor, HIGH-GRADE GLIOMAS, SURGICAL MICROSCOPE FILTER, LOW-COST DEVICE, BRAIN-TUMORS, 5-AMINOLEVULINIC ACID, SODIUM FLUORESCEIN, ANEURYSM SURGERY, BLOOD-FLOW, GUIDANCE, MODEL


OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from nontumor areas with a compromised bloode-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor tissue in an animal glioma model.