Akademik Veri Yönetim Sistemi
ACTA MEDICA MEDITERRANEA, cilt.38, sa.2, ss.991-1000, 2022 (SCI-Expanded)
Background/Aim: Since the announcement of SARS-CoV-2 virus infection (COVID-19) as a global pandemic at the beginning of March 2020 by the World Health Organization, dermatological manifestations of the infection have been encountered and publications on this topic have expanded. As an ongoing global pandemic, accumulation of new data has accelerated, and it has become a growing necessity to keep informed on current knowledge. The aim of these review series is to update published data on cutaneous manifestations of COVID-19 infection in adults and children (Part I) and adverse mucocutaneous reactions induced by medications and vaccines used for COVID-19 infection (Part II). Materials and methods: Literature search was performed in the databases PubMed, Scopus, and Web of Science for the relevant studies, starting from the beginning of COVID-19 pandemic until October 2021. Research on animals, studies utilizing in vitro techniques and publications irrelevant to the study???s framework were excluded. Results: The skin manifestations of COVID-19 are frequent, polymorphic, and versatile. Herein, cutaneous findings liable to COVID-19 disease have been detailed as urticarial, maculopapular, vesicular, and vascular lesions and latest data on skin manifestations has been presented. Recently reported skin manifestations in children with SARS-CoV-2 infection, namely multisystem inflammatory syndrome, has also been covered as a topic. Conclusion: There is a great amount of accumulated data regarding the cutaneous manifestations before, during and after COVID-19 infections. In the pandemic era, it is a major goal to elucidate pathognomonic, specific, or SARS-CoV-2 virus-related cutaneous signs and distinguish them from eruptions caused by medications, vaccines, and emotional stress. Owing to improvement and increased accessibility to diagnostic testing for COVID-19 infection and accelerated histopathological, immunological, and clinical investigations, the future holds promise for optimism in achieving that goal. Currently, it is known that cutaneous manifestations like vesicular and urticarial eruptions may also be present in asymptomatic individuals or develop before the onset of other symptoms of COVID-19 infection. In addition, some cutaneous manifestations may provide clues for prognosis. Furthermore, skin manifestations could be the sole clues in pediatric COVID-19 infections. Therefore, it is essential for physicians to update their knowledge regularly on skin manifestations of COVID-19 infection and mucocutaneous side effects of COVID-19 therapeutics and vaccines.