Clinical applications of MALDI imaging technologies in cancer and neurodegenerative diseases

Ucal Y., Durer Z. A., Atak H., Kadioglu E., Sahin B., COŞKUN A., ...Daha Fazla

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, cilt.1865, sa.7, ss.795-816, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 1865 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.bbapap.2017.01.005
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.795-816
  • Anahtar Kelimeler: MALDI-IMS, Cancer, Neurodegenerative diseases, Clinical application, SQUAMOUS-CELL CARCINOMA, LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 1, IONIZATION MASS-SPECTROMETRY, PARAFFIN-EMBEDDED TISSUE, HUMAN COLORECTAL-CANCER, BLOOD-BRAIN-BARRIER, FATTY-ACID SYNTHASE, HUMAN-BREAST-CANCER, IN-SOURCE DECAY, PROTEOMIC ANALYSIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) enables localization of analytes of interest along with histology. More specifically, MALDI-IMS identifies the distributions of proteins, peptides, small molecules, lipids, and drugs and their metabolites in tissues, with high spatial resolution. This unique capacity to directly analyze tissue samples without the need for lengthy sample preparation reduces technical variability and renders MALDI-IMS ideal for the identification of potential diagnostic and prognostic biomarkers and disease gradation. MALDI-IMS has evolved rapidly over the last decade and has been successfully used in both medical and basic research by scientists worldwide. In this review, we explore the clinical applications of MALDI-IMS, focusing on the major cancer types and neurodegenerative diseases. In particular, we re-emphasize the diagnostic potential of IMS and the challenges that must be confronted when conducting MALDI-IMS in clinical settings. (C) 2017 Elsevier B.V. All rights reserved.