Evidence for the presence of muscarinic M-2 and M-4 receptors in guinea-pig gallbladder smooth muscle

Oktay, S; Cabadak, H; Iskender, E; Goren, Z; Caliskan, E; Orun, O; Aslan, N; Karaalp, A; Tolun, A; Ulusoy, NB; Levey, AI; El-Fakahany, EE; KAN, BEKİ

doi:10.1046/j.1365-2680.1998.18474.x

Evidence for the presence of muscarinic M-2 and M-4 receptors in guinea-pig gallbladder smooth muscle

Atıf İçin Kopyala

Oktay S., Cabadak H., Iskender E., Goren Z., Caliskan E., Orun O., ...Daha Fazla

JOURNAL OF AUTONOMIC PHARMACOLOGY, cilt.18, sa.4, ss.195-204, 1998 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 4
Basım Tarihi: 1998
Doi Numarası: 10.1046/j.1365-2680.1998.18474.x
Dergi Adı: JOURNAL OF AUTONOMIC PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
Sayfa Sayıları: ss.195-204
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

1 The affinities of 10 selective muscarinic receptor antagonists against [H-3]-quinuclidinyl benzilate (QNB) binding were determined to characterize the muscarinic receptors present in guinea-pig gallbladder smooth muscle. The highest correlation was obtained for the comparison between the pK(i) values for the gallbladder smooth muscle and M-2 sites. Pirenzepine revealed two binding sites with affinities indicating the presence of muscarinic M-2 receptors in abundance and a minor population of an additional site(s).