Evidence for the presence of muscarinic M-2 and M-4 receptors in guinea-pig gallbladder smooth muscle


Oktay S., Cabadak H., Iskender E., Goren Z., Caliskan E., Orun O., ...More

JOURNAL OF AUTONOMIC PHARMACOLOGY, vol.18, no.4, pp.195-204, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 1998
  • Doi Number: 10.1046/j.1365-2680.1998.18474.x
  • Title of Journal : JOURNAL OF AUTONOMIC PHARMACOLOGY
  • Page Numbers: pp.195-204

Abstract

1 The affinities of 10 selective muscarinic receptor antagonists against [H-3]-quinuclidinyl benzilate (QNB) binding were determined to characterize the muscarinic receptors present in guinea-pig gallbladder smooth muscle. The highest correlation was obtained for the comparison between the pK(i) values for the gallbladder smooth muscle and M-2 sites. Pirenzepine revealed two binding sites with affinities indicating the presence of muscarinic M-2 receptors in abundance and a minor population of an additional site(s).