Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

Demir I. E., Heinrich T., Carty D. G., Saricaoglu O. C., Klauss S., Teller S., ...More

EBIOMEDICINE, vol.46, pp.431-443, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ebiom.2019.07.055
  • Journal Name: EBIOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.431-443
  • Keywords: Pain, Neurology of the digestive tract, nNOS, Nitrergic, Chronic pancreatitis, Pancreatic cancer, Genetically engineered mice, Atg5, NITRIC-OXIDE SYNTHASE, DUCTAL ADENOCARCINOMA, NEURONAL PLASTICITY, NEURAL PLASTICITY, SENSORY NEURONS, PROGRESSION, CELLS, INFLAMMATION, INITIATION, CANCER
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets.