Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis


Demir I. E. , Heinrich T., Carty D. G. , Saricaoglu O. C. , Klauss S., Teller S., ...More

EBIOMEDICINE, vol.46, pp.431-443, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ebiom.2019.07.055
  • Title of Journal : EBIOMEDICINE
  • Page Numbers: pp.431-443

Abstract

Background: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets.