Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

Demir, Ihsan; Heinrich, Tobias; Carty, Dominique; Saricaoglu, Omer; Klauss, Sarah; Teller, Steffen; Kehl, Timo; Reyes, Carmen; Tieftrunk, Elke; Lazarou, Maria; Bahceci, Dorukhan; Gokcek, Betul; Ucurum, Bahar; Maak, Matthias; Diakopoulos, Kalliope; Lesina, Marina; Schemann, Michael; Erkane, MURAT; Krueger, Achim; Algul, Hana; Friess, Helmut; Ceyhan, GÜRALP

doi:10.1016/j.ebiom.2019.07.055

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

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Demir I. E., Heinrich T., Carty D. G., Saricaoglu O. C., Klauss S., Teller S., ...More

EBIOMEDICINE, vol.46, pp.431-443, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 46
Publication Date: 2019
Doi Number: 10.1016/j.ebiom.2019.07.055
Journal Name: EBIOMEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.431-443
Keywords: Pain, Neurology of the digestive tract, nNOS, Nitrergic, Chronic pancreatitis, Pancreatic cancer, Genetically engineered mice, Atg5, NITRIC-OXIDE SYNTHASE, DUCTAL ADENOCARCINOMA, NEURONAL PLASTICITY, NEURAL PLASTICITY, SENSORY NEURONS, PROGRESSION, CELLS, INFLAMMATION, INITIATION, CANCER
Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets.