Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

Demir, Ihsan; Heinrich, Tobias; Carty, Dominique; Saricaoglu, Omer; Klauss, Sarah; Teller, Steffen; Kehl, Timo; Reyes, Carmen; Tieftrunk, Elke; Lazarou, Maria; Bahceci, Dorukhan; Gokcek, Betul; Ucurum, Bahar; Maak, Matthias; Diakopoulos, Kalliope; Lesina, Marina; Schemann, Michael; Erkane, MURAT; Krueger, Achim; Algul, Hana; Friess, Helmut; Ceyhan, GÜRALP

doi:10.1016/j.ebiom.2019.07.055

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis

Demir I. E., Heinrich T., Carty D. G., Saricaoglu O. C., Klauss S., Teller S., ...Daha Fazla

EBIOMEDICINE, cilt.46, ss.431-443, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.ebiom.2019.07.055
Dergi Adı: EBIOMEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.431-443
Anahtar Kelimeler: Pain, Neurology of the digestive tract, nNOS, Nitrergic, Chronic pancreatitis, Pancreatic cancer, Genetically engineered mice, Atg5, NITRIC-OXIDE SYNTHASE, DUCTAL ADENOCARCINOMA, NEURONAL PLASTICITY, NEURAL PLASTICITY, SENSORY NEURONS, PROGRESSION, CELLS, INFLAMMATION, INITIATION, CANCER
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Pain due to pancreatic cancer/PCa or chronic pancreatitis/CP, is notoriously resistant to the strongest pain medications. Here, we aimed at deciphering the specific molecular mediators of pain at surgical-stage pancreatic disease and to discover novel translational targets.