Long-Term Antiarrhythmic Effects of Thrombolytic Therapy in Pulmonary Embolism
HEART LUNG AND CIRCULATION, cilt.26, sa.10, ss.1094-1100, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 10
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.hlc.2016.11.016
- Dergi Adı: HEART LUNG AND CIRCULATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1094-1100
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Background The role of thrombolytic therapy in acute pulmonary embolism patients is still controversial considering the occurrence of arrhythmias. Short-term effects of thrombolytics are well-known whereas long-term effects on cardiac electrophysiology have not been reported before. The objective of our study was to assess the arrhythmic differences in pulmonary embolism patients who received thrombolytics followed by anticoagulation or anticoagulation alone. Methods Sixty patients who received thrombolytic therapy followed by anticoagulation (group 1) and 60 patients who received anticoagulation alone (group 2) were included in this retrospective, single-centre observational study. Twenty-four-hour ambulatory electrocardiography was performed 31 +/- 9 months after pulmonary embolism hospitalisation in order to compare arrhythmias originating from both ventricles and atria. Results The age and gender distribution of the patients were statistically similar. Ventricular arrhythmias were found to be the same between t-PA and non t-PA groups. All types of atrial arrhythmias were found to be increased in non t-PA group even though left and right atrial volume indexes were statistically identical between the two groups. Conclusion In long-term pulmonary embolism, follow-up thrombolytic therapy was demonstrated to have atrial antiarrhythmic effects.