Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature.


Kantarcioglu B., Kaygusuz-Atagunduz I., Uzay A. , TOPTAŞ T., Tuglular T. F. , Bayik M.

International journal of hematology, vol.102, no.3, pp.383-7, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 102 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1007/s12185-015-1792-2
  • Title of Journal : International journal of hematology
  • Page Numbers: pp.383-7

Abstract

The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.