Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature


Kantarcioglu B., Kaygusuz-Atagunduz I., Uzay A., TOPTAŞ T., Tuglular T. F. , Bayik M.

INTERNATIONAL JOURNAL OF HEMATOLOGY, cilt.102, ss.383-387, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 102 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s12185-015-1792-2
  • Dergi Adı: INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Sayfa Sayısı: ss.383-387

Özet

The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.