Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature
International Journal of Hematology, cilt.102, sa.3, ss.383-387, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 102 Sayı: 3
- Basım Tarihi: 2015
- Doi Numarası: 10.1007/s12185-015-1792-2
- Dergi Adı: International Journal of Hematology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.383-387
- Anahtar Kelimeler: BCR-JAK2, Fusion gene, JAK2 rearrangement, Myelodysplastic syndrome, t(9;22)
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.