JOURNAL OF NEURO-ONCOLOGY, vol.57, no.2, pp.115-121, 2002 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF NEURO-ONCOLOGY
central nervous system tumors, proliferative activity, grade, Ki-67, PCNA, CELL NUCLEAR ANTIGEN, BROMODEOXYURIDINE LABELING INDEX, MONOCLONAL-ANTIBODY KI-67, HUMAN-BRAIN TUMORS, PROGNOSTIC IMPLICATIONS, PROLIFERATIVE ACTIVITY, EXPRESSION, ASTROCYTOMAS, NEOPLASMS, CYCLE
Determination of proteins in the control of proliferation in normal cells helps a better understanding of cellular transformation and proliferation mechanisms. Measurement of proliferative activity is important in determining the tumor grade, recurrence span and malignancy. Proliferating cell nuclear antigen (PCNA) and Ki-67 are two of the nuclear markers used to demonstrate the proliferative phase of the cell cycle.