PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade


Kayaselcuk F., Zorludemir S., Gumurdulu D., Zeren H. , Erman T.

JOURNAL OF NEURO-ONCOLOGY, vol.57, no.2, pp.115-121, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1023/a:1015739130208
  • Title of Journal : JOURNAL OF NEURO-ONCOLOGY
  • Page Numbers: pp.115-121
  • Keywords: central nervous system tumors, proliferative activity, grade, Ki-67, PCNA, CELL NUCLEAR ANTIGEN, BROMODEOXYURIDINE LABELING INDEX, MONOCLONAL-ANTIBODY KI-67, HUMAN-BRAIN TUMORS, PROGNOSTIC IMPLICATIONS, PROLIFERATIVE ACTIVITY, EXPRESSION, ASTROCYTOMAS, NEOPLASMS, CYCLE

Abstract

Determination of proteins in the control of proliferation in normal cells helps a better understanding of cellular transformation and proliferation mechanisms. Measurement of proliferative activity is important in determining the tumor grade, recurrence span and malignancy. Proliferating cell nuclear antigen (PCNA) and Ki-67 are two of the nuclear markers used to demonstrate the proliferative phase of the cell cycle.