Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease

Akin, Hakan; Tahan, Gulgun; Ture, Filiz; EREN, FATİH; ATUĞ, ÖZLEN; Tahan, Veysel; Hamzaoglu, Ismail; Imeryuz, Nese; Tozun, AYŞE; Hamzaoglu, Hulya

doi:10.1016/j.crohns.2010.08.008

Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease

Akin H., Tahan G., Ture F., EREN F., ATUĞ Ö., Tahan V., ...Daha Fazla

JOURNAL OF CROHNS & COLITIS, cilt.5, sa.1, ss.14-18, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 1
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.crohns.2010.08.008
Dergi Adı: JOURNAL OF CROHNS & COLITIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.14-18
Anahtar Kelimeler: Inflammatory bowel disease, Bactericidal/permeability increasing protein, Pathogenesis, Polymorphism, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, CROHNS-DISEASE, ULCERATIVE-COLITIS, INNATE IMMUNITY, VARIANTS, MUTATION, TOLL, AUTOANTIBODIES, SUSCEPTIBILITY, PATHOGENESIS
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Increasing Increasing evidence suggests that innate immune system may have a key role in the pathogenesis of the inflammatory bowel disease (IBD). Bactericidal/permeability increasing protein (BPI) has an important role in the recognition and neutralization of gram-negative bacteria by host innate immune system. The polymorphism on BPI gene called Lys216Glu is on the suspected list of IBD pathogenesis.