Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study

Sahin I., SERTER R., Karakurt F., Demirbas B., Culha C., Taskapan C., ...Daha Fazla

GYNECOLOGICAL ENDOCRINOLOGY, cilt.19, sa.3, ss.115-124, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/09513590400004736
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-124
  • Anahtar Kelimeler: PCOS, insulin sensitivity, androgens, metformin, flutamide, ESTRADIOL-CYPROTERONE ACETATE, LOW-DOSE FLUTAMIDE, INSULIN-RESISTANCE, GONADOTROPIN-SECRETION, LUTEINIZING-HORMONE, OBESE WOMEN, ANTIANDROGEN TREATMENT, LEAN WOMEN, ANDROGEN, PITUITARY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In addition to the reproductive consequences, polycystic ovary syndrome (PCOS) is characterized by a metabolic disorder in which hyperinsulinemia and insulin resistance are central features. The effects and possible benefits from insulin-sensitizing, drugs are not well known, especially in non-obese women with PCOS. This study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS. Thirty non-obese women newly diagnosed with PCOS and 15 age- and weight-matched healthy volunteers as controls were included in the study. Patients were assigned randomly to receive flutamide 250 mg daily or metformin 850 mg three times daily. Glucose, insulin, insulin resistance, androgen levels and glucose and insulin responses to an oral glucose tolerance tests (OGTT) were assessed before and after a 4-week therapy period. A positive correlation was found between body mass index and insulin level in patients with PCOS and controls. Follicle stimulating hormone.