EFFICACY OF ANTI-SEROTONINERGIC AGENTS IN THE TREATMENT OF ERECTILE DYSFUNCTION


KURT U., OZKARDES H., ALTUG U. , GERMIYANOGLU C., GURDAL M., EROL D.

JOURNAL OF UROLOGY, cilt.152, ss.407-409, 1994 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 152 Konu: 2
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/s0022-5347(17)32750-7
  • Dergi Adı: JOURNAL OF UROLOGY
  • Sayfa Sayısı: ss.407-409

Özet

We investigated 3 agents with antiserotoninergic activity (oral trazodone, ketanserin and mianserin) in a double-blind randomized placebo controlled design in terms of the effectiveness in erectile dysfunction. Positive response rates to 30 days of treatment were 65.2% with trazodone, 19.1% with ketanserin, 31.6% with mianserin and 13.6% with placebo. Response to trazodone treatment was significantly better than with placebo (p = 0.0004) and the other 2 agents (p = 0.03 and p = 0.002 for mianserin and ketanserin, respectively). The effectiveness of ketanserin and mianserin seemed to be greater than that of placebo but the differences did not reach statistical significance (p = 0.63 and p = 0.17, respectively).