Extracts from peppermint leaves, lemon balm leaves and in particular angelica roots mimic the pro-secretory action of the herbal preparation STW 5 in the human intestine

Allam S., Krueger D., Demir I. E. , Ceyhan G. O. , Zeller F., Schemann M.

PHYTOMEDICINE, vol.22, no.12, pp.1063-1070, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1016/j.phymed.2015.08.008
  • Title of Journal : PHYTOMEDICINE
  • Page Numbers: pp.1063-1070


Aim: The herbal preparation STW 5 contains fresh plant extracts from bitter candytuft whole plant, extracts from greater celandine herb, angelica root, lemon balm leaves, peppermint leaves, caraway fruit, liquorice root, chamomile flower and milk thistle fruit. We recently reported that STW 5 increased intestinal chloride secretion and proposed that this action may be involved in its clinical efficacy in the treatment of irritable bowel syndrome. The aim of this study was to identify the extracts responsible for the secretory action in order to provide the basis to develop novel target oriented herbal combinations.