Akademik Veri Yönetim Sistemi
Foot and Ankle Clinics, cilt.10, sa.4, ss.595-608, 2005 (Scopus)
Given the aforementioned biologic basis, coupled with the clinical data to support it, PLIUS has been demonstrated clearly to accelerate the healing process in fractures. The literature indicates that PLIUS can have a positive impact on the prevention of complications, such as loss of reduction or slow healing, and that the prevention of nonunions is likely. There is clear evidence of an ability to resolve established nonunions that are not responding to conventional treatment, as well as delayed unions or slow healing fractures. The data supports the efficacy of PLIUS in all bones (excluding skull and vertebra), all types of fracture, and as an adjunctive treatment to all types of primary fracture management. Additional evidence supports application of PLIUS for the mitigation of risk factors, such as smoking, disease state, or medication use, some of which may need to be proven definitively. Also, occurrences may exist where PLIUS does not offer benefit, either fractures which are likely to heal optimally without any adjunctive treatments or those that heal by mechanisms other than endochondral ossification. © 2005 Elsevier Inc. All rights reserved.