Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response

Muckenhuber, Alexander; Berger, Anne; Schlitter, Anna; Steiger, Katja; Konukiewitz, Bjoern; Trumpp, Andreas; Eils, Roland; Werner, Jens; Friess, Helmut; Esposito, Irene; Kloeppel, Guenter; Ceyhan, GÜRALP; Jesinghaus, Moritz; Denkert, Carsten; Bahra, Marcus; Stenzinger, Albrecht; Sprick, Martin; Jaeger, Dirk; Springfeld, Christoph; Weichert, Wilko

doi:10.1158/1078-0432.ccr-17-2180

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response

Muckenhuber A., Berger A. K., Schlitter A. M., Steiger K., Konukiewitz B., Trumpp A., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.24, sa.2, ss.351-359, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 2
Basım Tarihi: 2018
Doi Numarası: 10.1158/1078-0432.ccr-17-2180
Dergi Adı: CLINICAL CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.351-359
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis and poor therapeutic response to current chemotherapy regimens in unselected patient populations. Recently, it has been shown that PDAC may be stratified into functionally and therapeutically relevant molecular subgroups and that some of these subtypes can be recapitulated by IHC for KRT81 [quasi-mesenchymal (QM)/squamous/basal-like] and HNF1A (non-QM, overlap with exocrine/ADEX subtype).